Pulmodual/Pulmodual MDI Drug Interactions

Pulmodual: Anticholinergic agents: Co-administration of other anticholinergic containing drugs must be avoided. It can cause an additive interaction upon concomitant use of anticholinergic medications.
Beta-adrenergic agents: Caution is advised in the co-administration of Ipratropium bromide + Salbutamol and other sympathomimetic agents due to the increased risk of adverse cardiovascular effects.
Beta-receptor blocking agents: Beta-receptor blocking agents and Salbutamol inhibit the effect of each other, it should be used with caution in patients with hyper reactive airways.
Cardiac glycosides: Salbutamol possibly reduces plasma concentration of digoxin.
Diuretics: Increased risk of hypokalemia when high doses of beta₂ sympathomimetics is given with diuretics (e.g. loop or thiazide diuretics).
Monoamine oxidase inhibitors or tricyclic antidepressants: It should be administered with extreme caution to patients treated with monoamine oxidase inhibitors or tricyclic antidepressants or within two weeks of discontinuation of such agents because the action of salbutamol sulfate on the cardiovascular system may be potentiated.
Theophylline: Increased risk of hypokalemia when high doses of beta₂ sympathomimetics is given with theophylline.
Pulmodual MDI: The healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring the patient for it. Do not start, stop or change the dosage of any medicine before checking with them first. Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication. In some cases a serious, possibly fatal drug interaction may occur. Before using this medication, tell the doctor or pharmacist of all prescription and non-prescription/herbal product the patient may be using, especially of: anticholinergic drugs (e.g., atropine, scopolamine), certain antihistamine (e.g., diphenhydramine, meclizine), antispasmodic drugs (e.g., dicyclomine, hyoscyamine), certain anti-Parkinson's drugs (e.g., benztropine, trihexyphenidyl), some beta-blockers (such as propranolol), bladder control drugs (e.g., oxybutynin, tolterodine), pramlintide, stimulant-like drugs (e.g., ephedrine, epinephrine), tricyclic antidepressants (e.g., amitriptyline, nortriptyline), certain "water pills" (diuretics that cause potassium loss from the body such as furosemide, hydrochlorothiazide). Check the labels on all the patient's medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase the patient's heart rate or blood pressure. Ask the pharmacist about the safe use of those products. This monograph does not contain all the possible interactions. Therefore, before using this product, tell the doctor or pharmacist of all the products the patient uses. Keep a list of all the patient's medications with the patient, and share the list with the doctor and pharmacist.